Publications

2022

Taylor M. Chavez and Sharon Gerecht, ‘Engineering of the microenvironment to accelerate vascular regeneration.’, Trends in Molecular Medicine, 2022 [https://doi.org/10.1016/j.molmed.2022.10.005 ].

Ariel Isser, Aliyah B. Silver, Hawley C. Pruitt, Michal Mass, Emma H. Elias, Gohta Aihara, Si-Sim Kang, Niklas Bachmann, Ying-Yu Chen, Elissa K. Leonard, Joan G. Bieler, Worarat Chaisawangwong, Joseph Choy, Sydney R. Shannon, Sharon Gerecht, Jeffrey S. Weber, Jamie B. Spangler and Jonathan P. Schneck,  ‘Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy’, Nature Communications, vol. 13, 2022, p. 6086 [https://doi.org/https://doi.org/10.1038/s41467-022-33597-y ].

Eugenia Volkova, Linda Procell, Lingyang Kong, Lakshmi Santhanam, and Sharon Gerecht, ‘Vascular stiffening in aging females with a hypertension-induced HIF2A gain-of-function mutation.’, Bioengineering & Translational Medicine, 2022, p. e10403 [https://doi.org/https://doi.org/10.1002/btm2.10403 ].

Danielle Yarbrough and Sharon Gerecht, ‘Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease’, Bioengineering, vol. 9, no. 9, 2022, p. 449 [https://doi.org/https://doi.org/10.3390/bioengineering9090449 ].

Morgan B. Elliott, Hiroshi Matsushit, Jessica Shen, Jaeyoon Yi, Takahiro Inoue, Travis Brady, Lakshmi Santhanam, Hai-Quan Mao, Narutoshi Hibino and Sharon Gerecht, ‘Off-the-shelf, heparinized small diameter vascular graft limits acute thrombogenicity in a porcine model’, Acta Biomaterialia, 2022 [https://doi.org/10.1016/j.actbio.2022.07.061 ].

Dimitris Ntekoumes and Sharon Gerecht, ‘Tissue Engineering Approaches to Uncover Therapeutic Targets for Endothelial Dysfunction in Pathological Microenvironments’, International Journal of Molecular Sciences, vol. 23, no. 13, 2022 [https://doi.org/10.3390/ijms23137416 ].

Rahel Schnellmann, Dimitris Ntekoumes, Mohammad Ikbal Choudhury, Sean Sun, Zhao Wei and Sharon Gerecht, ‘Stiffening Matrix Induces Age-Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions’, Advanced Science, 2022, p. 2201483 [https://doi.org/10.1002/advs.202201483 ].

Bria L. Macklin, Ying-Yu Lin, Kevin Emmerich, Emily Wisniewski, Brian M. Polster, Konstantinos Konstantopoulos, Jeff S. Mumm and Sharon Gerecht, ‘Intrinsic epigenetic control of angiogenesis in induced pluripotent stem cell-derived endothelium regulates vascular regeneration’, npj Regenerative Medicine, vol. 7, no. 1, 2022, p. 28 [https://doi.org/10.1038/s41536-022-00223-w ].

John J. Jamieson, YingYu Lin, Nora A. Malloy, Daniel Soto, Peter C. Searson and Sharon Gerecht, ‘Hypoxia-induced blood-brain barrier dysfunction is prevented by pericyte-conditioned media via attenuated actomyosin contractility and claudin-5 stabilization’, The FASEB Journal, vol. 36, no. 5, 2022, p. e22331 [https://doi.org/10.1096/fj.202200010RR ].

2021

Juhyun Lee, Sharon Gerecht, Hanjoong Jo and Tzung Hsiai, Modern Mechanobiology: Convergence of Biomechanics, Development and Genomics, 1st edition, Jenny Stanford Publishing, 2021, https://www.amazon.com/Modern-Mechanobiology-Convergence-Biomechanics-Development-ebook/dp/B08QRPD9V9 ].

Nguyen, Jane, Ying-Yu Lin, and Sharon Gerecht, ‘The next generation of endothelial differentiation: Tissue-specific ECs.’, Cell stem cell, vol. 28, no. 7, 2021, pp. 1188–204 [https://doi.org/10.1016/j.stem.2021.05.002 ].

Michael R. Blatchley, Franklyn Hall, Dimitris Ntekoumes, Hyunwoo Cho, Vidur Kailash, Rafael Vazquez-Duhalt and Sharon Gerecht, ‘Discretizing Three-Dimensional Oxygen Gradients to Modulate and Investigate Cellular Processes’, Advanced Science, vol. 8, no. 14, 2021, p. 2100190 [https://doi.org/10.1002/advs.202100190 ].

Xin Yi Chan, Eugenia Volkova, Joon Eoh, Rebecca Black, Lilly Fang, Rayyan Gorashi, Jihyun Song, Jing Wang, Morgan B. Elliott, Sebastian F. Barreto-Ortiz, James Chen, Brian L. Lin, Lakshmi Santhanam, Linzhao Cheng, Frank S. Lee, Josef  T. Prchal and Sharon Gerecht, ‘HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics.’, iScience, vol. 24, no. 4, 2021, p. 102246 [https://doi.org/10.1016/j.isci.2021.102246 ].

2020

Jia Jia, Eun Je Jeon, Mei Li, Dylan J. Richards, Soojin Lee, Youngmee Jung, Ryan W. Barrs, Robert Coyl, Xiaoyang Li, James C. Chou, Michael J. Yost, Sharon Gerecht, Seung-Woo Cho and Ying Mei, ‘Evolutionarily conserved sequence motif analysis guides development of chemically defined hydrogels for therapeutic vascularization’, Science Advances, vol. 6, no. 28, 2020, p. eaaz5894 [https://doi.org/10.1126/sciadv.aaz5894 ].

Zhao Wei, Rahel Schnellmann, Hawley C. Pruitt, Sharon Gerecht, ‘Hydrogel Network Dynamics Regulate Vascular Morphogenesis.’, Cell stem cell, vol. 27, no. 5, 2020, pp. 798-812.e6 [https://doi.org/10.1016/j.stem.2020.08.005 ].

Hawley C. Pruitt and Sharon Gerecht, ‘Modeling metastasis: engineering approaches to study the metastatic cascade’, Progress in Biomedical Engineering, 2020 [https://doi.org/10.1088/2516-1091/abc34f ].

Justin Lowenthal and Sharon Gerecht, ‘If You Build It, They Will Come’, Circulation Research, vol. 127, no. 2, 2020, pp. 225–8 [https://doi.org/10.1161/CIRCRESAHA.120.317111 ].

Hongkwan Cho, Bria L. Macklin, Ying-Yu Lin, Lingli Zhou, Michael J. Lai, Grace Lee, Sharon Gerecht and Elia J. Duh, ‘iPSC-derived endothelial cell response to hypoxia via SDF1a/CXCR4 axis facilitates incorporation to revascularize ischemic retina’, JCI Insight, vol. 5, no. 6, 2020 [https://doi.org/10.1172/jci.insight.131828 ].

Isaree Pitaktong, Cecillia Lui, Justin Lowenthal, Gunnar Mattson, Wei-Hung Jung, Yang Bai, Enoch Yeung, Chin Siang Ong, Yun Chen, Sharon Gerecht and Narutoshi Hibino, ‘Early Vascular Cells Improve Microvascularization Within 3D Cardiac Spheroids’, Tissue Engineering Part C: Methods, vol. 26, no. 2, 2020, pp. 80–90 [https://doi.org/10.1089/ten.tec.2019.0228 ].

Michael R. Blatchley and Sharon Gerecht, ‘Reconstructing the Vascular Developmental Milieu In Vitro.’, Trends in cell biology, vol. 30, no. 1, 2020, pp. 15–31 [https://doi.org/10.1016/j.tcb.2019.10.004 ].

Hawley C.Pruitt, Daniel Lewis, Mark Ciccaglione, Sydney Connor, Quinton Smith, John W. Hickey, Jonathan P. Schneck and Sharon Gerecht, ‘Collagen fiber structure guides 3D motility of cytotoxic T lymphocytes’, Matrix Biomechanics, vols 85–86, 2020, pp. 147–59 [https://doi.org/10.1016/j.matbio.2019.02.003 ].

2019

Michael R. Blatchley, Franklyn Hall, Songnan Wang, Hawley C. Pruitt and Sharon Gerecht, ‘Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesis’, Science Advances, vol. 5, no. 3, 2019, p. eaau7518 [https://doi.org/10.1126/sciadv.aau7518 ].

Zhao Wei, Eugenia Volkova, Michael R. Blatchley and Sharon Gerecht, ‘Hydrogel vehicles for sequential delivery of protein drugs to promote vascular regeneration’, Sequential Drug/Gene Delivery in Tissue Engineering & Regenerative Medicine, vols 149–150, 2019, pp. 95–106 [https://doi.org/10.1016/j.addr.2019.08.005 ].

Yang Xiao, Chang Liu, Zhuo Chen, Michael R. Blatchley, Dongjoo Kim, Jing Zhou, Ming Xu, Sharon Gerecht and Rong Fan, ‘Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs’, Advanced Biosystems, vol. 3, no. 8, 2019, p. 1900089 [https://doi.org/10.1002/adbi.201900089 ]

Morgan B. Elliott, Brian Ginn, Takuma Fukunishi, Djahida Bedja, Abhilash Suresh, Theresa Chen, Takahiro Inoue, Harry C. Dietz, Lakshmi Santhanam, Hai-Quan Mao, Narutoshi Hibino and Sharon Gerecht ‘Regenerative and durable small-diameter graft as an arterial conduit’, Proceedings of the National Academy of Sciences, vol. 116, no. 26, 2019, p. 12710 [https://doi.org/10.1073/pnas.1905966116 ].

John J. Jamieson, Raleigh M. Linville, Yuan Yuan Ding, Sharon Gerecht and Peter C. Searson, ‘Role of iPSC-derived pericytes on barrier function of iPSC-derived brain microvascular endothelial cells in 2D and 3D’, Fluids and Barriers of the CNS, vol. 16, no. 1, 2019, p. 15 [https://doi.org/10.1186/s12987-019-0136-7 ].

John J. Jamieson and Sharon Gerecht, ‘Chipping Away at Blood-Brain-Barrier Modeling.’, Cell stem cell, vol. 24, no. 6, 2019, pp. 831–2 [https://doi.org/10.1016/j.stem.2019.05.014 ].

John W. Hickey, Yi Dong, Jae Wook Chung, Sebastian F. Salathe, Hawley C. Pruitt, Xiaowei Li, Calvin Chang, Andrew K. Fraser, Catherine A. Bessell, Andrew J. Ewald, Sharon Gerecht, Hai-Quan Mao and Jonathan P. Schneck ‘Engineering an Artificial T-Cell Stimulating Matrix for Immunotherapy’, Advanced Materials, vol. 31, no. 23, 2019, p. 1807359 [https://doi.org/10.1002/adma.201807359 ].

Hongkwan Cho, Michael R. Blatchley, Elia J. Duh and Sharon Gerecht, ‘Acellular and cellular approaches to improve diabetic wound healing’, Wound healing and fibrosis – State of play, vol. 146, 2019, pp. 267–88 [https://doi.org/10.1016/j.addr.2018.07.019 ].

Adriana Blazeski, Justin Lowenthal, Yin Wang, Roald Teuben, Renjun Zhu, Sharon Gerecht, Gordon Tomaselli and Leslie Tung, ‘Engineered Heart Slice Model of Arrhythmogenic Cardiomyopathy Using Plakophilin-2 Mutant Myocytes’, Tissue Engineering Part A, vol. 25, nos. 9–10, 2019, pp. 725–35 [https://doi.org/10.1089/ten.tea.2018.0272 ].

Daniel M. Lewis, Hawley Pruitt, Nupur Jain, Mark Ciccaglione, J. Michael McCaffery, Zhiyong Xia, Kristy Weber, T.S. Karin Eisinger-Mathason and Sharon Gerecht, ‘A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma’, Cancer Research, vol. 79, no. 8, 2019, p. 1981 [https://doi.org/10.1158/0008-5472.CAN-18-1984 ].

2018

Gina Wadas, ‘Bioengineers Borrow from Electronics Industry to Get Stem Cells to Shape Up’, Johns Hopkins University HUB, 2018.

John Jamieson, Bria Macklin and Sharon Gerecht, ‘Pericyte Derived from Pluripotent Stem Cells’, in Biology of Pericytes: Development, Homeostasis and Disease; Advances in Experimental Medicine and Biology, Springer, 2018, [https://doi.org/10.1007/978-3-030-02601-1_9].

Sharon Gerecht, Biophysical Regulation of Vascular Differentiation and Assembly, Springer, 2018.

Xin Yi Chan, Morgan B. Elliott, Bria Macklin  and Sharon Gerecht, ‘Human Pluripotent Stem Cells to Engineer Blood Vessels’, in Engineering and Application of Pluripotent Stem Cells, ed. by Ulrich Martin, Robert Zweigerdt, and Ina Gruh, Cham: Springer International Publishing, 2018, pp. 147–68 [https://doi.org/10.1007/10_2017_28 ].

Zhao Wei and Sharon Gerecht, ‘A self-healing hydrogel as an injectable instructive carrier for cellular morphogenesis’, Biomaterials, vol. 185, 2018, pp. 86–96 [https://doi.org/10.1016/j.biomaterials.2018.09.003].

Quinton Smith, Nash Rochman, Ana Maria Carmo, Dhruv Vig, Xin Yi Chan, Sean Sun and Sharon Gerecht,  ‘Cytoskeletal tension regulates mesodermal spatial organization and subsequent vascular fate’, Proceedings of the National Academy of Sciences, vol. 115, no. 32, 2018, p. 8167 [https://doi.org/10.1073/pnas.1808021115].

Quinton Smith, Bria Macklin, Xin Yi Chan, Hannah Jones, Michelle Trempel, Mervin C. Yoder and Sharon Gerecht, ‘Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells.’, Cell reports, vol. 24, no. 4, 2018, pp. 895-908.e6 [https://doi.org/10.1016/j.celrep.2018.06.083].

Sausan M.Jaberab, Evan A. Bordta, Niraj M. Bhatta, Daniel M. Lewis, Sharon Gerecht, Gary Fiskuma and Brian M. Polster, ‘Sex differences in the mitochondrial bioenergetics of astrocytes but not microglia at a physiologically relevant brain oxygen tension’, Mitochondria in the Nervous System: From Health to Disease Part 2, vol. 117, 2018, pp. 82–90 [https://doi.org/10.1016/j.neuint.2017.09.003].

Daniel M. Lewis, Nicholas Mavrogiannis, Zachary Gagnon  and Sharon Gerecht, ‘Microfluidic platform for the real time measurement and observation of endothelial barrier function under shear stress’, Biomicrofluidics, vol. 12, no. 4, 2018, pp. 042202–042202 [https://doi.org/10.1063/1.5026901 ].

Quinton Smith and Sharon Gerecht, ‘Extracellular Matrix Regulation of Stem Cell Fate’, Current Stem Cell Reports, vol. 4, no. 1, 2018, pp. 13–21 [https://doi.org/10.1007/s40778-018-0111-2 ].

Chan, Xin Yi, Joon H. Eoh, and Sharon Gerecht, ‘Let’s get physical: Biomechanical influences on human pluripotent stem cell differentiation towards vascular engineering’, Futures of Biomedical Engineering: Cardiovascular Bioengineering and Vascular Biomechanics, vol. 5, 2018, pp. 42–9 [https://doi.org/10.1016/j.cobme.2018.01.001 ].

Daniel M. Lewis, Vitor Tang, Nupur Jain, Ariel Isser, Zhiyong Xia and Sharon Gerecht, ‘Collagen Fiber Architecture Regulates Hypoxic Sarcoma Cell Migration’, ACS Biomaterials Science & Engineering, vol. 4, no. 2, 2018, pp. 400–9 [https://doi.org/10.1021/acsbiomaterials.7b00056 ].

Michael R. Blatchley, Hasan E. Abaci, Donny Hanjaya-Putra and Sharon Gerecht,  ‘Hypoxia and Matrix Manipulation for Vascular Engineering’, in Biophysical Regulation of Vascular Differentiation and Assembly, 2018, pp. 73–119 [https://doi.org/10.1007/978-3-319-99319-5_4 ].

2017

Jamieson, John J., Peter C. Searson, and Sharon Gerecht, ‘Engineering the human blood-brain barrier in vitro’, Journal of Biological Engineering, vol. 11, no. 1, 2017, p. 37 [https://doi.org/10.1186/s13036-017-0076-1 ].

Blatchley, Michael R. and Sharon Gerecht, ‘Integrin binding: Sticking around vessels’, Nature Materials, vol. 16, 2017, pp. 881–3 [https://doi.org/10.1038/nmat4977 ].

Wei, Zhao et al., ‘Dual Cross-Linked Biofunctional and Self-Healing Networks to Generate User-Defined Modular Gradient Hydrogel Constructs’, Advanced Healthcare Materials, vol. 6, no. 16, 2017, p. 1700523 [https://doi.org/10.1002/adhm.201700523 ].

Lewis, Daniel M. et al., ‘O2-controllable hydrogels for studying cellular responses to hypoxic gradients in three dimensions in vitro and in vivo’, Nature Protocols, vol. 12, no. 8, 2017, pp. 1620–38 [https://doi.org/10.1038/nprot.2017.059 ].

Park, Kyung Min, Daniel Lewis, and Sharon Gerecht, ‘Bioinspired Hydrogels to Engineer Cancer Microenvironments’, Annual Review of Biomedical Engineering, vol. 19, no. 1, 2017, pp. 109–33 [https://doi.org/10.1146/annurev-bioeng-071516-044619 ].

Smith, Quinton et al., ‘Compliant substratum guides endothelial commitment from human pluripotent stem cells’, Science advances, vol. 3, no. 5, 2017, pp. e1602883–e1602883 [https://doi.org/10.1126/sciadv.1602883 ].

Eoh, Joon H. et al., ‘Enhanced elastin synthesis and maturation in human vascular smooth muscle tissue derived from induced-pluripotent stem cells’, Extracellular Matrix Proteins and Mimics, vol. 52, 2017, pp. 49–59 [https://doi.org/10.1016/j.actbio.2017.01.083 ].

Kusuma, Sravanti et al., ‘Micropattern size-dependent endothelial differentiation from a human induced pluripotent stem cell line’, Journal of Tissue Engineering and Regenerative Medicine, vol. 11, no. 3, 2017, pp. 855–61 [https://doi.org/10.1002/term.1985 ].

Macklin, Bria L. and Sharon Gerecht, ‘Bridging the gap: induced pluripotent stem cell derived endothelial cells for 3D vascular assembly’, Biological engineering / Materials Engineering, vol. 15, 2017, pp. 102–9 [https://doi.org/10.1016/j.coche.2017.01.003 ].

Smith, Quinton, Michael Blatchley, and Sharon Gerecht, ‘Engineering Niches for Blood Vessel Regeneration’, in Biology and Engineering of Stem Cell Niches, ed. by Ajaykumar Vishwakarma and Jeffrey M. Karp, Boston: Academic Press, 2017, pp. 479–97 [https://doi.org/10.1016/B978-0-12-802734-9.00030-5 ].

 

2016

Kusuma, Sravanti and Sharon Gerecht, ‘Derivation of Endothelial Cells and Pericytes from Human Pluripotent Stem Cells.’, Methods in molecular biology (Clifton, N.J.), vol. 1307, 2016, pp. 213–22 [https://doi.org/10.1007/7651_2014_149 ].

Elliott, Morgan B. and Sharon Gerecht, ‘Three-dimensional culture of small-diameter vascular grafts.’, Journal of materials chemistry. B, vol. 4 20, 2016, pp. 3443–53, https://pubs.rsc.org/en/content/articlelanding/2016/tb/c6tb00024j.

Dickinson, Laura E. and Sharon Gerecht, ‘Engineered Biopolymeric Scaffolds for Chronic Wound Healing’, Frontiers in Physiology, vol. 7, 2016, p. 341 [https://doi.org/10.3389/fphys.2016.00341 ].

Smith, Quinton and Sharon Gerecht, ‘Stem Cell Fate Is a Touchy Subject.’, Cell stem cell, vol. 19, no. 3, 2016, pp. 289–90 [https://doi.org/10.1016/j.stem.2016.08.015 ].

Shen, Yu-I. et al., ‘Engineered human vascularized constructs accelerate diabetic wound healing’, Biomaterials, vol. 102, 2016, pp. 107–19 [https://doi.org/10.1016/j.biomaterials.2016.06.009 ].

Lewis, Daniel M. et al., ‘Intratumoral oxygen gradients mediate sarcoma cell invasion’, Proceedings of the National Academy of Sciences, vol. 113, no. 33, 2016, p. 9292 [https://doi.org/10.1073/pnas.1605317113 ].

Lowenthal, Justin and Sharon Gerecht, ‘Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering’, Special Issue: Stem Cells, vol. 473, no. 3, 2016, pp. 733–42 [https://doi.org/10.1016/j.bbrc.2015.09.127 ].

Katt, Moriah E. et al., ‘Human Brain Microvascular Endothelial Cells Derived from the BC1 iPS Cell Line Exhibit a Blood-Brain Barrier Phenotype’, PLOS ONE, vol. 11, no. 4, 2016, p. e0152105 [https://doi.org/10.1371/journal.pone.0152105 ].

Lewis, Daniel M. and Sharon Gerecht, ‘Microfluidics and biomaterials to study angiogenesis’, Biological Engineering / Material Engineering, vol. 11, 2016, pp. 114–22 [https://doi.org/10.1016/j.coche.2016.02.005 ].

Hielscher, Abigail et al., ‘Fibronectin Deposition Participates in Extracellular Matrix Assembly and Vascular Morphogenesis’, PLOS ONE, vol. 11, no. 1, 2016, p. e0147600 [https://doi.org/10.1371/journal.pone.0147600 ].

Burdick, Jason A., Robert L. Mauck, and Sharon Gerecht, ‘To Serve and Protect: Hydrogels to Improve Stem Cell-Based Therapies.’, Cell stem cell, vol. 18, no. 1, 2016, pp. 13–5 [https://doi.org/10.1016/j.stem.2015.12.004 ].

Janmey, Paul et al., Physical Sciences and Engineering Advances in Life Sciences and Oncology: A WTEC Global Assessment, 2016 [https://doi.org/10.1007/978-3-319-17930-8 ].
Wang, Ying et al., ‘Scalable Production of Human Erythrocytes from Induced Pluripotent Stem Cells’, bioRxiv, 2016, p. 050021 [https://doi.org/10.1101/050021 ].

2015

Blatchley, Michael, Kyung Min Park, and Sharon Gerecht, ‘Designer hydrogels for precision control of oxygen tension and mechanical properties’, Journal of Materials Chemistry B, vol. 3, no. 40, 2015, pp. 7939–49 [https://doi.org/10.1039/C5TB01038A ].

Lewis, Daniel M. et al., ‘Endothelial progenitor cell recruitment in a microfluidic vascular model’, Biofabrication, vol. 7, no. 4, 2015, p. 045010 [https://doi.org/10.1088/1758-5090/7/4/045010 ].

Chan, Xin Yi et al., ‘Three-Dimensional Vascular Network Assembly From Diabetic Patient-Derived Induced Pluripotent Stem Cells’, Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 35, no. 12, 2015, pp. 2677–85 [https://doi.org/10.1161/ATVBAHA.115.306362 ].

Bogorad, Max I. et al., ‘Review: in vitro microvessel models.’, Lab on a chip, vol. 15, no. 22, 2015, pp. 4242–55 [https://doi.org/10.1039/c5lc00832h ].

Park, Kyung Min and Sharon Gerecht, ‘Polymeric hydrogels as artificial extracellular microenvironments for cancer research’, European Polymer Journal, vol. 72, 2015, pp. 507–13 [https://doi.org/10.1016/j.eurpolymj.2015.06.030 ].

Shen, Yu-I. et al., ‘Acellular Hydrogels for Regenerative Burn Wound Healing: Translation from a Porcine Model’, Journal of Investigative Dermatology, vol. 135, no. 10, 2015, pp. 2519–29 [https://doi.org/10.1038/jid.2015.182 ].

Wanjare, Maureen, Nayan Agarwal, and Sharon Gerecht, ‘Biomechanical strain induces elastin and collagen production in human pluripotent stem cell-derived vascular smooth muscle cells’, American Journal of Physiology-Cell Physiology, vol. 309, no. 4, 2015, pp. C271–81 [https://doi.org/10.1152/ajpcell.00366.2014 ].

Barreto-Ortiz, Sebastian F. et al., ‘Fabrication of 3-dimensional multicellular microvascular structures’, The FASEB Journal, vol. 29, no. 8, 2015, pp. 3302–14 [https://doi.org/10.1096/fj.14-263343 ].

Smith, Quinton et al., ‘Stochasticity and Spatial Interaction Govern Stem Cell Differentiation Dynamics’, Scientific Reports, vol. 5, no. 1, 2015, p. 12617 [https://doi.org/10.1038/srep12617 ].

Eisinger-Mathason, T.S. Karin et al., ‘Deregulation of the Hippo pathway in soft-tissue sarcoma promotes FOXM1 expression and tumorigenesis’, Proceedings of the National Academy of Sciences, 2015, p. 201420005 [https://doi.org/10.1073/pnas.1420005112 ].

Blatchley, Michael R. and Sharon Gerecht, ‘Acellular implantable and injectable hydrogels for vascular regeneration’, Biomedical Materials, vol. 10, no. 3, 2015, p. 034001 [https://doi.org/10.1088/1748-6041/10/3/034001 ].

Kusuma, Sravanti, Amanda Facklam, and Sharon Gerecht, ‘Characterizing Human Pluripotent-Stem-Cell-Derived Vascular Cells for Tissue Engineering Applications’, Stem Cells and Development, vol. 24, no. 4, 2015, pp. 451–8 [https://doi.org/10.1089/scd.2014.0377 ].

Hielscher, Abigail and Sharon Gerecht, ‘Hypoxia and free radicals: Role in tumor progression and the use of engineering-based platforms to address these relationships’, Free Radical Biology and Medicine, vol. 79, 2015, pp. 281–91 [https://doi.org/10.1016/j.freeradbiomed.2014.09.015 ].

2014

Shen, Yu-I. et al., ‘Hyaluronic acid hydrogel stiffness and oxygen tension affect cancer cell fate and endothelial sprouting’, Biomaterials Science, vol. 2, no. 5, 2014, pp. 655–65 [https://doi.org/10.1039/C3BM60274E ].

Kusuma, Sravanti, Bria Macklin, and Sharon Gerecht, ‘Derivation and network formation of vascular cells from human pluripotent stem cells.’, Methods in molecular biology (Clifton, N.J.), vol. 1202, 2014, pp. 1–9 [https://doi.org/10.1007/7651_2013_39 ].

Barreto-Ortiz, Sebastian F., Quinton Smith, and Sharon Gerecht, ‘Vascular Development and Morphogenesis in Biomaterials’, in Vascularization, 1st edition, CRC Press, 2014, p. 24, https://www.taylorfrancis.com/chapters/edit/10.1201/b16777-9/vascular-development-morphogenesis-biomaterials-sebastian-barreto-ortiz-quinton-smith-sharon-gerecht].

Song, Hyun-Ho Greco, Kyung Min Park, and Sharon Gerecht, ‘Hydrogels to model 3D in vitro microenvironment of tumor vascularization’, Engineering of tumor microenvironments, vols 79–80, 2014, pp. 19–29 [https://doi.org/10.1016/j.addr.2014.06.002 ].

Park, Kyung Min, Michael R. Blatchley, and Sharon Gerecht, ‘The Design of Dextran-Based Hypoxia-Inducible Hydrogels via In Situ Oxygen-Consuming Reaction’, Macromolecular Rapid Communications, vol. 35, no. 22, 2014, pp. 1968–75 [https://doi.org/10.1002/marc.201400369 ].

Park, Kyung Min and Sharon Gerecht, ‘Harnessing developmental processes for vascular engineering and regeneration’, Development, vol. 141, no. 14, 2014, pp. 2760–9 [https://doi.org/10.1242/dev.102194 ].

Wang, Ying, Linzhao Cheng, and Sharon Gerecht, ‘Efficient and Scalable Expansion of Human Pluripotent Stem Cells Under Clinically Compliant Settings: A View in 2013’, Annals of Biomedical Engineering, vol. 42, no. 7, 2014, pp. 1357–72 [https://doi.org/10.1007/s10439-013-0921-4 ].

Park, Kyung Min and Sharon Gerecht, ‘Hypoxia-inducible hydrogels’, Nature Communications, vol. 5, no. 1, 2014, p. 4075 [https://doi.org/10.1038/ncomms5075 ].

Stahl, Patrick J. et al., ‘Capillary Network-Like Organization of Endothelial Cells in PEGDA Scaffolds Encoded with Angiogenic Signals via Triple Helical Hybridization’, Advanced Functional Materials, vol. 24, no. 21, 2014, pp. 3213–25 [https://doi.org/10.1002/adfm.201303217 ].

Abaci, Hasan Erbil et al., ‘Recapitulating physiological and pathological shear stress and oxygen to model vasculature in health and disease’, Scientific Reports, vol. 4, no. 1, 2014, p. 4951 [https://doi.org/10.1038/srep04951 ].

Wanjare, Maureen, Sravanti Kusuma, and Sharon Gerecht, ‘Defining differences among perivascular cells derived from human pluripotent stem cells’, Stem cell reports, vol. 2, no. 5, 2014, pp. 561–75 [https://doi.org/10.1016/j.stemcr.2014.03.004 ].

Kusuma, Sravanti et al., ‘Low Oxygen Tension Enhances Endothelial Fate of Human Pluripotent Stem Cells’, Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 34, no. 4, 2014, pp. 913–20 [https://doi.org/10.1161/ATVBAHA.114.303274 ].

Zhang, Shuming et al., ‘Creating polymer hydrogel microfibres with internal alignment via electrical and mechanical stretching’, Biomaterials, vol. 35, no. 10, 2014, pp. 3243–51 [https://doi.org/10.1016/j.biomaterials.2013.12.081 ].

Smith, Quinton and Sharon Gerecht, ‘Going with the flow: microfluidic platforms in vascular tissue engineering’, Biological engineering / Materials engineering, vol. 3, 2014, pp. 42–50 [https://doi.org/10.1016/j.coche.2013.11.001 ].

Kusuma, S., L.E. Dickinson, and S. Gerecht, ‘Cell–biomaterial interactions for blood vessel formation’, in Cardiac Regeneration and Repair, ed. by Ren-Ke Li and Richard D. Weisel, Woodhead Publishing, 2014, pp. 350–88 [https://doi.org/10.1533/9780857096715.3.350 ].

2013

SciBX, Synthetic Vascular Networks Derived from Human Pluripotent Stem Cells, 2013, https://link.springer.com/article/10.1038/scibx.2013.845.

Park, Kyung Min and Sharon Gerecht, ‘Reconstruction of the differentiation niche of embryonic stem cells using biomaterials to direct stem cell fate’, in Cell and Molecular Biology and Imaging of Stem Cells, 2013, https://sites.duke.edu/gerechtlab/publications/.

Hirsch, Arthur, ‘Lab-grown Blood Vessels Made with Less Ado’, Baltimore Sun, 2013, https://www.baltimoresun.com/health/bs-hs-sci-bloodvessels-20131004-story.html.

Hielscher, Abigail et al., ‘Hypoxia Affects the Structure of Breast Cancer Cell-Derived Matrix to Support Angiogenic Responses of Endothelial Cells.’, Journal of carcinogenesis & mutagenesis, vol. Suppl 13, 2013, p. 005 [https://doi.org/10.4172/2157-2518.S13-005 ].

Contie, Vicki, ‘Stem Cells Coaxed to Create Working Blood Vessels’, NIH Research Matters, 2013, https://www.nih.gov/news-events/nih-research-matters/stem-cells-coaxed-create-working-blood-vessels.

Barreto-Ortiz, Sebastian F. et al., ‘A Novel In Vitro Model for Microvasculature Reveals Regulation of Circumferential ECM Organization by Curvature’, PLOS ONE, vol. 8, no. 11, 2013, p. e81061 [https://doi.org/10.1371/journal.pone.0081061 ].

Wang, Ying et al., ‘Scalable expansion of human induced pluripotent stem cells in the defined xeno-free E8 medium under adherent and suspension culture conditions’, Stem Cell Research, vol. 11, no. 3, 2013, pp. 1103–16 [https://doi.org/10.1016/j.scr.2013.07.011 ].

Smulovitz, Courtney, Laura E. Dickinson, and Sharon Gerecht, ‘Micropatterned Surfaces for the Study of Cancer and Endothelial Cell Interactions with Hyaluronic Acid’, Israel Journal of Chemistry, vol. 53, nos. 9–10, 2013, pp. 710–8 [https://doi.org/10.1002/ijch.201300058 ].

Kusuma, Sravanti and Sharon Gerecht, ‘Fast and furious: the mass and motion of stem cells.’, Biophysical journal, vol. 105, no. 4, 2013, pp. 837–8 [https://doi.org/10.1016/j.bpj.2013.07.021 ].

Kusuma, Sravanti et al., ‘Self-organized vascular networks from human pluripotent stem cells in a synthetic matrix’, Proceedings of the National Academy of Sciences, 2013, p. 201306562 [https://doi.org/10.1073/pnas.1306562110 ].

Kusuma, Sravanti and Sharon Gerecht, ‘Recent progress in the use of induced pluripotent stem cells in vascular regeneration.’, Expert review of cardiovascular therapy, vol. 11, no. 6, 2013, pp. 661–3 [https://doi.org/10.1586/erc.13.54 ].

Hanjaya-Putra, Donny et al., ‘Integration and regression of implanted engineered human vascular networks during deep wound healing.’, Stem cells translational medicine, vol. 2, no. 4, 2013, pp. 297–306 [https://doi.org/10.5966/sctm.2012-0111 ].

Agus, David B. et al., ‘A physical sciences network characterization of non-tumorigenic and metastatic cells’, Scientific Reports, vol. 3, no. 1, 2013, p. 1449 [https://doi.org/10.1038/srep01449 ].

Wanjare, Maureen, Sravanti Kusuma, and Sharon Gerecht, ‘Perivascular cells in blood vessel regeneration’, Biotechnology Journal, vol. 8, no. 4, 2013, pp. 434–47 [https://doi.org/10.1002/biot.201200199 ].

ABACI, HASAN E., GERMAN DRAZER, and SHARON GERECHT, ‘RECAPITULATING THE VASCULAR MICROENVIRONMENT IN MICROFLUIDIC PLATFORMS’, Nano LIFE, vol. 03, no. 01, 2013, p. 1340001 [https://doi.org/10.1142/S1793984413400011 ].

Wanjare, Maureen, Frederick Kuo, and Sharon Gerecht, ‘Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells.’, Cardiovascular research, vol. 97, no. 2, 2013, pp. 321–30 [https://doi.org/10.1093/cvr/cvs315 ].

Serbo, Janna V. and Sharon Gerecht, ‘Vascular tissue engineering: biodegradable scaffold platforms to promote angiogenesis.’, Stem cell research & therapy, vol. 4, no. 1, 2013, p. 8 [https://doi.org/10.1186/scrt156 ].

2012

Sun, Guoming, Sravanti Kusuma, and Sharon Gerecht, ‘Development of a biodegradable, temperature-sensitive dextran-based polymer as a cell-detaching substrate.’, Macromolecular bioscience, vol. 12, no. 1, 2012, pp. 21–8 [https://doi.org/10.1002/mabi.201100258 ].

Abaci, Hasan E. et al., ‘Design and development of microbioreactors for long-term cell culture in controlled oxygen microenvironments’, Biomedical Microdevices, vol. 14, no. 1, 2012, pp. 145–52 [https://doi.org/10.1007/s10544-011-9592-9 ].

Hielscher, Abigail C., Connie Qiu, and Sharon Gerecht, ‘Breast cancer cell-derived matrix supports vascular morphogenesis’, American Journal of Physiology-Cell Physiology, vol. 302, no. 8, 2012, pp. C1243–56 [https://doi.org/10.1152/ajpcell.00011.2012 ].

Abaci, Hasan E. et al., ‘Microbioreactors to manipulate oxygen tension and shear stress in the microenvironment of vascular stem and progenitor cells.’, Biotechnology and applied biochemistry, vol. 59, no. 2, 2012, pp. 97–105 [https://doi.org/10.1002/bab.1010 ].

Khatau, Shyam B. et al., ‘The Differential Formation of the LINC-Mediated Perinuclear Actin Cap in Pluripotent and Somatic Cells’, PLOS ONE, vol. 7, no. 5, 2012, p. e36689 [https://doi.org/10.1371/journal.pone.0036689 ].

Dickinson, Laura E. et al., ‘Endothelial cell responses to micropillar substrates of varying dimensions and stiffness.’, Journal of biomedical materials research. Part A, vol. 100, no. 6, 2012, pp. 1457–66 [https://doi.org/10.1002/jbm.a.34059 ].

Hanjaya-Putra, Donny et al., ‘Spatial control of cell-mediated degradation to regulate vasculogenesis and angiogenesis in hyaluronan hydrogels’, Biomaterials, vol. 33, no. 26, 2012, pp. 6123–31 [https://doi.org/10.1016/j.biomaterials.2012.05.027 ].

Hielscher, Abigail C. and Sharon Gerecht, ‘Engineering approaches for investigating tumor angiogenesis: exploiting the role of the extracellular matrix.’, Cancer research, vol. 72, no. 23, 2012, pp. 6089–96 [https://doi.org/10.1158/0008-5472.CAN-12-2773 ].

Kusuma, Sravanti, Stephen Zhao, and Sharon Gerecht, ‘The extracellular matrix is a novel attribute of endothelial progenitors and of hypoxic mature endothelial cells’, The FASEB Journal, vol. 26, no. 12, 2012, pp. 4925–36 [https://doi.org/10.1096/fj.12-209296 ].

Hielscher, Abigail, Yu-I. Shen, and Sharon Gerecht, ‘Engineering bioactive scaffolds for stem cell vascular therapy’, in Stem Cells – From Mechanisms to Technologies, 2012, https://sites.duke.edu/gerechtlab/publications/.

SciBX, Dextran-based Hydrogel Scaffold for Burn Wound Skin Regeneration, 2012, https://link.springer.com/article/10.1038/scibx.2012.55.

Selimovic, S. et al., ‘Culturing Endothelial Cell on Micropillars’, Lab Chip, 2012, https://sites.duke.edu/gerechtlab/publications/.

‘Stem Cells Prodded into Two Tissue Types Essential for Growing Blood Vessels’, Stem Cells Transl Med 2, 2012, https://sites.duke.edu/gerechtlab/publications/.

2011

Sun, Guoming et al., ‘Functional neovascularization of biodegradable dextran hydrogels with multiple angiogenic growth factors’, Biomaterials, vol. 32, no. 1, 2011, pp. 95–106 [https://doi.org/10.1016/j.biomaterials.2010.08.091 ].

Dickinson, Laura E., Sravanti Kusuma, and Sharon Gerecht, ‘Reconstructing the differentiation niche of embryonic stem cells using biomaterials.’, Macromolecular bioscience, vol. 11, no. 1, 2011, pp. 36–49 [https://doi.org/10.1002/mabi.201000245 ].

Yee, Derek et al., ‘Hyaluronic Acid hydrogels support cord-like structures from endothelial colony-forming cells.’, Tissue engineering. Part A, vol. 17, nos. 9–10, 2011, pp. 1351–61 [https://doi.org/10.1089/ten.TEA.2010.0481 ].

Hanjaya-Putra, Donny et al., ‘Controlled activation of morphogenesis to generate a functional human microvasculature in a synthetic matrix.’, Blood, vol. 118, no. 3, 2011, pp. 804–15 [https://doi.org/10.1182/blood-2010-12-327338 ].

Abaci, Hasan Erbil et al., ‘Unforeseen decreases in dissolved oxygen levels affect tube formation kinetics in collagen gels.’, American journal of physiology. Cell physiology, vol. 301, no. 2, 2011, pp. C431-440 [https://doi.org/10.1152/ajpcell.00074.2011 ].

Barreto-Ortiz, Sebastian Felipe and Sharon Gerecht, ‘Research Highlights’, Regenerative Medicine, vol. 6, no. 5, 2011, pp. 551–4 [https://doi.org/10.2217/rme.11.53 ].

Sun, Guoming et al., ‘Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing’, Proceedings of the National Academy of Sciences, vol. 108, no. 52, 2011, p. 20976 [https://doi.org/10.1073/pnas.1115973108 ].

Abaci, Hasan, Donny Putra, and Sharon Gerecht, ‘Hypoxia and Matrix Manipulation for Vascular Engineering’, in Biophysical Regulation of Vascular Differentiation and Assembly, 2011 [https://doi.org/10.1007/978-3-319-99319-5_4 ].

Boyle, Rebecca, ‘Wound-Treating Jelly Regenerates Fresh, Scar-Free Skin’, Popular Science, 2011, https://www.popsci.com/technology/article/2011-12/new-wound-treating-jelly-regenerates-fresh-scar-free-skin/.

Dickinson, Laura and Sharon Gerecht, ‘Stem cells for vascular regeneration: an engineering approach’, in Stem Cell and Tissue Engineering, 2011, https://sites.duke.edu/gerechtlab/publications/.

Geissler, EK and P. Angele, ‘Innovative Blood Vessels Bring New Life’, Blood 118, 2011, https://ashpublications.org/blood/article/118/3/488/28911/Innovative-blood-vessels-bring-new-life.

Gerecht, Sharon, Biophysical Regulation of Vascular Differentiation and Assembly, Springer, 2011, https://sites.duke.edu/gerechtlab/publications/.

Hanjaya-Putra, Donny, M. Wangare, and Sharon Gerecht, ‘Vascular Tissue Engineering’, in Biomaterials for Tissue Engineering: A Review of the Past and Future Trends, 2011, https://sites.duke.edu/gerechtlab/publications/.

In Third-Degree Burn Treatment, Hydrogel Helps Grow New, Scar-Free Skin’, Science Daily, 2011, https://www.sciencedaily.com/releases/2011/12/111213131956.htm.

Palucka, Tim, ‘Hydrogel Material Speeds Burn Wound Healing with Complete Skin Regeneration’, Materials Research Society, Materials 360 The Global View, 2011, https://sites.duke.edu/gerechtlab/publications/.

Sun, Guoming, Sravanti Kusuma, and Sharon Gerecht, ‘The integrated role of stem cells and biomaterials in vascular regeneration’, in Mechanobiology, Tissue Engineering and Biomaterials, 2011, https://www.researchgate.net/publication/225312605_The_Integrated_Role_of_Biomaterials_and_Stem_Cells_in_Vascular_Regeneration.

2010

Abaci, Hasan Erbil et al., ‘Adaptation to oxygen deprivation in cultures of human pluripotent stem cells, endothelial progenitor cells, and umbilical vein endothelial cells’, American Journal of Physiology-Cell Physiology, vol. 298, no. 6, 2010, pp. C1527–37 [https://doi.org/10.1152/ajpcell.00484.2009 ].

Sun, Guoming et al., ‘Functional groups affect physical and biological properties of dextran-based hydrogels.’, Journal of biomedical materials research. Part A, vol. 93, no. 3, 2010, pp. 1080–90 [https://doi.org/10.1002/jbm.a.32604 ].

Dickinson, Laura E. et al., ‘Functional surfaces for high-resolution analysis of cancer cell interactions on exogenous hyaluronic acid’, Biomaterials, vol. 31, no. 20, 2010, pp. 5472–8 [https://doi.org/10.1016/j.biomaterials.2010.03.044 ].

Hanjaya-Putra, Donny et al., ‘Vascular endothelial growth factor and substrate mechanics regulate in vitro tubulogenesis of endothelial progenitor cells.’, Journal of cellular and molecular medicine, vol. 14, no. 10, 2010, pp. 2436–47 [https://doi.org/10.1111/j.1582-4934.2009.00981.x ].

Kusuma, Sravanti and Sharon Gerecht, ‘Engineering blood vessels using stem cells: innovative approaches to treat vascular disorders.’, Expert review of cardiovascular therapy, vol. 8, no. 10, 2010, pp. 1433–45 [https://doi.org/10.1586/erc.10.121 ].

Daniels, Brian R. et al., ‘Differences in the microrheology of human embryonic stem cells and human induced pluripotent stem cells.’, Biophysical journal, vol. 99, no. 11, 2010, pp. 3563–70 [https://doi.org/10.1016/j.bpj.2010.10.007 ].

Dickinson, Laura E. and Sharon Gerecht, ‘Micropatterned Surfaces to Study Hyaluronic Acid Interactions with Cancer Cells’, JoVE, no. 46, 2010, p. e2413 [https://doi.org/10.3791/2413 ].

Dickinson, Laura E., Matthew E. Moura, and Sharon Gerecht, ‘Guiding endothelial progenitor cell tube formation using patterned fibronectin surfaces’, Soft Matter, vol. 6, no. 20, 2010, pp. 5109–19 [https://doi.org/10.1039/C0SM00233J ].

Gerecht, Sharon, Lino S. Ferreira, and Robert Langer, ‘Vascular Differentiation of Human Embryonic Stem Cells in Bioactive Hydrogel-Based Scaffolds’, in Human Embryonic Stem Cell Protocols, ed. by Kursad Turksen, Totowa, NJ: Humana Press, 2010, pp. 333–54 [https://doi.org/10.1007/978-1-60761-369-5_18 ].

2009

Hanjaya-Putra, Donny and Sharon Gerecht, ‘Vascular engineering using human embryonic stem cells.’, Biotechnology progress, vol. 25, no. 1, 2009, pp. 2–9 [https://doi.org/10.1002/btpr.129 ].

Sun, Guoming and Sharon Gerecht, ‘Vascular regeneration: engineering the stem cell microenvironment’, Regenerative Medicine, vol. 4, no. 3, 2009, pp. 435–47 [https://doi.org/10.2217/rme.09.1 ].

Mei, Ying et al., ‘Mapping the Interactions among Biomaterials, Adsorbed Proteins, and Human Embryonic Stem Cells’, Advanced Materials, vol. 21, no. 27, 2009, pp. 2781–6 [https://doi.org/10.1002/adma.200803184 ].

Kusuma, Sravanti and Sharon Gerecht, ‘Research Highlights’, Regenerative Medicine, vol. 4, no. 6, 2009, pp. 805–7 [https://doi.org/10.2217/rme.09.57 ].

Hanjaya-Putra, Donny and Sharon Gerecht, ‘Preview. Mending the failing heart with a vascularized cardiac patch.’, Cell stem cell, vol. 5, no. 6, 2009, pp. 575–6 [https://doi.org/10.1016/j.stem.2009.11.005 ].

Serena, Elena et al., ‘Electrical stimulation of human embryonic stem cells: Cardiac differentiation and the generation of reactive oxygen species’, Experimental Cell Research, vol. 315, no. 20, 2009, pp. 3611–9 [https://doi.org/10.1016/j.yexcr.2009.08.015 ].

Luong, E. and S. Gerecht, ‘Stem Cells and Scaffolds for Vascularizing Engineered Tissue Constructs’, in Engineering of Stem Cells, ed. by Ulrich Martin, Berlin, Heidelberg: Springer Berlin Heidelberg, 2009, pp. 129–72 [https://doi.org/10.1007/10_2008_8 ].

2008

Godier, Amandine F.G. et al., ‘Engineered microenvironments for human stem cells.’, Birth defects research. Part C, Embryo today : reviews, vol. 84, no. 4, 2008, pp. 335–47 [https://doi.org/10.1002/bdrc.20138 ].

Bettinger, Christopher J. et al., ‘Enhancement of In Vitro Capillary Tube Formation by Substrate Nanotopography.’, Advanced materials (Deerfield Beach, Fla.), vol. 20, no. 1, 2008, pp. 99–103 [https://doi.org/10.1002/adma.200702487 ].

Shen, Yu-I. and Sharon Gerecht, Stem Cells and Materials for Vascular Differentiation and Regeneration, 2008, pp. 11–3, [https://sites.duke.edu/gerechtlab/publications/].

2007

Ferreira, Lino S. et al., ‘Bioactive hydrogel scaffolds for controllable vascular differentiation of human embryonic stem cells’, Biomaterials, vol. 28, no. 17, 2007, pp. 2706–17 [https://doi.org/10.1016/j.biomaterials.2007.01.021 ].

Gerecht, Sharon et al., ‘Hyaluronic acid hydrogel for controlled self-renewal and differentiation of human embryonic stem cells’, Proceedings of the National Academy of Sciences, vol. 104, no. 27, 2007, p. 11298 [https://doi.org/10.1073/pnas.0703723104 ].

Ferreira, Lino S. et al., ‘Vascular Progenitor Cells Isolated From Human Embryonic Stem Cells Give Rise to Endothelial and Smooth Muscle–Like Cells and Form Vascular Networks In Vivo’, Circulation Research, vol. 101, no. 3, 2007, pp. 286–94 [https://doi.org/10.1161/CIRCRESAHA.107.150201 ].

Radisic, M. et al., ‘Biomimetic approach to cardiac tissue engineering’, Philosophical transactions of the Royal Society of London. Series B, Biological sciences, vol. 362, no. 1484, 2007, pp. 1357–68 [https://doi.org/10.1098/rstb.2007.2121 ].

Gerecht, Sharon et al., ‘The effect of actin disrupting agents on contact guidance of human embryonic stem cells’, Biomaterials, vol. 28, no. 28, 2007, pp. 4068–77 [https://doi.org/10.1016/j.biomaterials.2007.05.027 ].

Leor, Jonathan et al., ‘Human embryonic stem cell transplantation to repair the infarcted myocardium’, Heart, vol. 93, no. 10, 2007, p. 1278 [https://doi.org/10.1136/hrt.2006.093161 ].

Gerecht, Sharon et al., ‘A porous photocurable elastomer for cell encapsulation and culture’, Biomaterials, vol. 28, no. 32, 2007, pp. 4826–35 [https://doi.org/10.1016/j.biomaterials.2007.07.039 ].

Cannizzaro, Christopher et al., ‘Practical aspects of cardiac tissue engineering with electrical stimulation.’, Methods in molecular medicine, vol. 140, 2007, pp. 291–307 [https://doi.org/10.1007/978-1-59745-443-8_16 ].

Figallo, Elisa et al., ‘Micro-bioreactor array for controlling cellular microenvironments’, Lab Chip, vol. 7, no. 6, 2007, pp. 710–9 [https://doi.org/10.1039/B700063D ].

Gerecht, Sharon et al., ‘Three-dimensional Culture of Human Embryonic Stem Cells’, in Human Cell Culture: Volume VI: Embryonic Stem Cells, ed. by John R. Masters, Bernhard O. Palsson, and James A.Thomson, Dordrecht: Springer Netherlands, 2007, pp. 149–72 [https://doi.org/10.1007/978-1-4020-5983-4_9 ].

Khademhosseini*, A., JM Karp*, and Sharon Gerecht*, ‘Embryonic Stem Cells as a Cell Source for Tissue Engineering’, in Principles of Tissue Enginering, 2007, https://www.sciencedirect.com/science/article/pii/B9780128184226000277.

2006

Dolnikov, Katya et al., ‘Functional properties of human embryonic stem cell-derived cardiomyocytes: intracellular Ca2+ handling and the role of sarcoplasmic reticulum in the  contraction.’, Stem cells (Dayton, Ohio), vol. 24, no. 2, 2006, pp. 236–45 [https://doi.org/10.1634/stemcells.2005-0036 ].

Gerecht-Nir, Sharon and Joseph Itskovitz-Eldor, ‘Differentiation of Human Embryonic Stem Cells’, in Embryonic Stem Cells – A Practical Approach, 2006, https://sites.duke.edu/gerechtlab/publications/.

Gerecht-Nir, Sharon et al., ‘Biophysical regulation during cardiac development and application to tissue engineering.’, The International journal of developmental biology, vol. 50, nos. 2–3, 2006, pp. 233–43 [https://doi.org/10.1387/ijdb.052041sg ].

2005

Gerecht-Nir, Sharon et al., ‘Vascular gene expression and phenotypic correlation during differentiation of human embryonic stem cells.’, Developmental dynamics : an official publication of the American Association of Anatomists, vol. 232, no. 2, 2005, pp. 487–97 [https://doi.org/10.1002/dvdy.20247 ].

Dolnikov, Katya et al., ‘Functional properties of human embryonic stem cell-derived cardiomyocytes.’, Annals of the New York Academy of Sciences, vol. 1047, 2005, pp. 66–75 [https://doi.org/10.1196/annals.1341.006 ].

Segev, Hanna et al., ‘Molecular analysis of cardiomyocytes derived from human embryonic stem cells.’, Development, growth & differentiation, vol. 47, no. 5, 2005, pp. 295–306 [https://doi.org/10.1111/j.1440-169X.2005.00803.x ].

Amit, Michal, Sharon Gerecht-Nir, and Joseph Itskovitz-Eldor, ‘Derivation, Subcloning, Spontaneous and Controlled Differentiation of Human Embryonic Stem Cells’, in Stem Cells – From Bench to Beside, 2005, https://sites.duke.edu/gerechtlab/publications/.

Golan-Mashiach, Michal et al., ‘Design principle of gene expression used by human stem cells: implication for pluripotency’, The FASEB Journal, vol. 19, no. 1, 2005, pp. 147–9 [https://doi.org/https://doi.org/10.1096/fj.04-2417fje ].

2004

Gerecht-Nir, Sharon, Bettina Fishman, and Joseph Itskovitz-Eldor, ‘Cardiovascular potential of embryonic stem cells’, The Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, vol. 276A, no. 1, 2004, pp. 58–65 [https://doi.org/10.1002/ar.a.10136 ].

Suss Toby, Edith et al., ‘Derivation of a diploid human embryonic stem cell line from a mononuclear zygote’, Human Reproduction, vol. 19, no. 3, 2004, pp. 670–5 [https://doi.org/10.1093/humrep/deh135 ].

Gerecht-Nir, Sharon and Joseph Itskovitz-Eldor, ‘Cell therapy using human embryonic stem cells’, Organogenesis and Tissue Engineering in Transplantation Medicine, vol. 12, no. 3, 2004, pp. 203–9 [https://doi.org/10.1016/j.trim.2003.12.013 ].

Ginis, Irene et al., ‘Differences between human and mouse embryonic stem cells’, Developmental Biology, vol. 269, no. 2, 2004, pp. 360–80 [https://doi.org/10.1016/j.ydbio.2003.12.034 ].

Gerecht-Nir, Sharon, Smadar Cohen, and Joseph Itskovitz-Eldor, ‘Bioreactor cultivation enhances the efficiency of human embryoid body (hEB) formation and differentiation.’, Biotechnology and bioengineering, vol. 86, no. 5, 2004, pp. 493–502 [https://doi.org/10.1002/bit.20045 ].

Gerecht-Nir, Sharon et al., ‘Three-dimensional porous alginate scaffolds provide a conducive environment for generation of well-vascularized embryoid bodies from human embryonic stem cells.’, Biotechnology and bioengineering, vol. 88, no. 3, 2004, pp. 313–20 [https://doi.org/10.1002/bit.20248 ].

Gerecht-Nir, Sharon and Joseph Itskovitz-Eldor, ‘The promise of human embryonic stem cells’, Stem Cells in Obstetrics and Gynaecology, vol. 18, no. 6, 2004, pp. 843–52 [https://doi.org/10.1016/j.bpobgyn.2004.07.004 ].

Gerecht-Nir, Sharon et al., ‘Vascular Development in Early Human Embryos and in Teratomas Derived from Human Embryonic Stem Cells1’, Biology of Reproduction, vol. 71, no. 6, 2004, pp. 2029–36 [https://doi.org/10.1095/biolreprod.104.031930 ].

Dang, Stephen M. et al., ‘Controlled, scalable embryonic stem cell differentiation culture.’, Stem cells (Dayton, Ohio), vol. 22, no. 3, 2004, pp. 275–82 [https://doi.org/10.1634/stemcells.22-3-275 ].

Gerecht-Nir, Sharon and Joseph Itskovitz-Eldor, ‘Vascular Progenitor Cells in the Human Model’, in Handbook of Embryonic Stem Cells, 2004, https://sites.duke.edu/gerechtlab/publications/.

Gerecht-Nir, Sharon and Joseph Itskovitz-Eldor, ‘Human embryonic stem cells: a potential source for cellular therapy.’, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 4 Suppl 6, 2004, pp. 51–7 [https://doi.org/10.1111/j.1600-6135.2004.0345.x ].

2003

Gerecht-Nir, Sharon et al., ‘Human embryonic stem cells for cardiovascular repair’, Cardiovascular Research, vol. 58, no. 2, 2003, pp. 313–23 [https://doi.org/10.1016/S0008-6363(03)00264-5 ].

Gerecht-Nir, Sharon et al., ‘Human embryonic stem cells as an in vitro model for human vascular development and the induction of vascular differentiation.’, Laboratory investigation; a journal of technical methods and pathology, vol. 83, no. 12, 2003, pp. 1811–20 [https://doi.org/10.1097/01.lab.0000106502.41391.f0 ].

Gerecht-Nir, Sharon and Itskovitz‐Eldor, ‘Vascular Lineage Differentiation from Human Embryonic Stem Cells’, in Human Embryonic Stem Cells, 2003, https://sites.duke.edu/gerechtlab/publications/.

Gerecht-Nir, Sharon, Liron Eldor, and Joseph Itskovitz‐Eldor, ‘Advances in Human Stem Cell Research’, Clinical Obstetrics and Gynecology, vol. 46, no. 2, 2003, https://journals.lww.com/clinicalobgyn/Fulltext/2003/06000/Advances_in_Human_Stem_Cell_Research.4.aspx.

2001

Zemel, R. et al., ‘Cell transformation induced by hepatitis C virus NS3 serine protease.’, Journal of viral hepatitis, vol. 8, no. 2, 2001, pp. 96–102 [https://doi.org/10.1046/j.1365-2893.2001.00283.x ].

Shapira, R. et al., ‘Transfusion-transmitted virus in liver-transplanted children’, Transplantation Proceedings, vol. 33, no. 6, 2001, pp. 2957–8 [https://doi.org/10.1016/S0041-1345(01)02270-9 ].

Chavez, Taylor M. and Sharon Gerecht, ‘Engineering of the microenvironment to accelerate vascular regeneration.’, Trends in Molecular Medicine, 2022 [https://doi.org/10.1016/j.molmed.2022.10.005 ].
Isser, Ariel et al., ‘Nanoparticle-based modulation of CD4+ T cell effector and helper functions enhances adoptive immunotherapy’, Nature Communications, vol. 13, 2022, p. 6086 [https://doi.org/https://doi.org/10.1038/s41467-022-33597-y ].
Volkova, Eugenia et al., ‘Vascular stiffening in aging females with a hypertension-induced HIF2A gain-of-function mutation.’, Bioengineering & Translational Medicine, 2022, p. e10403 [https://doi.org/https://doi.org/10.1002/btm2.10403 ].
Yarbrough, Danielle and Sharon Gerecht, ‘Engineering Smooth Muscle to Understand Extracellular Matrix Remodeling and Vascular Disease’, Bioengineering, vol. 9, no. 9, 2022, p. 449 [https://doi.org/https://doi.org/10.3390/bioengineering9090449 ].
Elliott, Morgan B. et al., ‘Off-the-shelf, heparinized small diameter vascular graft limits acute thrombogenicity in a porcine model’, Acta Biomaterialia, 2022 [https://doi.org/10.1016/j.actbio.2022.07.061 ].
Ntekoumes, Dimitris and Sharon Gerecht, ‘Tissue Engineering Approaches to Uncover Therapeutic Targets for Endothelial Dysfunction in Pathological Microenvironments’, International Journal of Molecular Sciences, vol. 23, no. 13, 2022 [https://doi.org/10.3390/ijms23137416 ].
Schnellmann, Rahel et al., ‘Stiffening Matrix Induces Age-Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions’, Advanced Science, 2022, p. 2201483 [https://doi.org/10.1002/advs.202201483 ].
Macklin, Bria L. et al., ‘Intrinsic epigenetic control of angiogenesis in induced pluripotent stem cell-derived endothelium regulates vascular regeneration’, npj Regenerative Medicine, vol. 7, no. 1, 2022, p. 28 [https://doi.org/10.1038/s41536-022-00223-w ].
Jamieson, John J. et al., ‘Hypoxia-induced blood-brain barrier dysfunction is prevented by pericyte-conditioned media via attenuated actomyosin contractility and claudin-5 stabilization’, The FASEB Journal, vol. 36, no. 5, 2022, p. e22331 [https://doi.org/10.1096/fj.202200010RR ].
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