Publications

Ntekoumes, Dimitris, and Sharon Gerecht. “Tissue Engineering Approaches to Uncover Therapeutic Targets for Endothelial Dysfunction in Pathological Microenvironments.” International Journal of Molecular Sciences, vol. 23, no. 13, July 2022, https://doi.org/10.3390/ijms23137416.
Schnellmann, Rahel, et al. “Stiffening Matrix Induces Age-Mediated Microvascular Phenotype Through Increased Cell Contractility and Destabilization of Adherens Junctions.” Advanced Science, June 2022, p. 2201483, https://doi.org/10.1002/advs.202201483.
Macklin, Bria L., et al. “Intrinsic Epigenetic Control of Angiogenesis in Induced Pluripotent Stem Cell-Derived Endothelium Regulates Vascular Regeneration.” Npj Regenerative Medicine, vol. 7, no. 1, May 2022, p. 28, https://doi.org/10.1038/s41536-022-00223-w.
Jamieson, John J., et al. “Hypoxia-Induced Blood-Brain Barrier Dysfunction Is Prevented by Pericyte-Conditioned Media via Attenuated Actomyosin Contractility and Claudin-5 Stabilization.” The FASEB Journal, vol. 36, no. 5, May 2022, p. e22331, https://doi.org/10.1096/fj.202200010RR.
Elliott, Morgan B., et al. “Off-the-Shelf, Heparinized Small Diameter Vascular Graft Limits Acute Thrombogenicity in a Porcine Model.” Acta Biomater, vol. In Press, 2022.
Blatchley, Michael R., et al. “Discretizing Three-Dimensional Oxygen Gradients to Modulate and Investigate Cellular Processes.” Advanced Science, vol. 8, no. 14, July 2021, p. 2100190, https://doi.org/10.1002/advs.202100190.
Nguyen, Jane, et al. “The next Generation of Endothelial Differentiation: Tissue-Specific ECs.” Cell Stem Cell, vol. 28, no. 7, July 2021, pp. 1188–204, https://doi.org/10.1016/j.stem.2021.05.002.
Chan, Xin Yi, et al. “HIF2A Gain-of-Function Mutation Modulates the Stiffness of Smooth Muscle Cells and Compromises Vascular Mechanics.” IScience, vol. 24, no. 4, Apr. 2021, p. 102246, https://doi.org/10.1016/j.isci.2021.102246.
Lee, Juhyun, et al. Modern Mechanobiology: Convergence of Biomechanics, Development and Genomics. 1st ed., Jenny Stanford Publishing, 2021, https://www.amazon.com/Modern-Mechanobiology-Convergence-Biomechanics-Development-ebook/dp/B08QRPD9V9.
Wei, Zhao, et al. “Hydrogel Network Dynamics Regulate Vascular Morphogenesis.” Cell Stem Cell, vol. 27, no. 5, Nov. 2020, pp. 798-812.e6, https://doi.org/10.1016/j.stem.2020.08.005.
Pruitt, Hawley Christine, and Sharon Gerecht. “Modeling Metastasis: Engineering Approaches to Study the Metastatic Cascade.” Progress in Biomedical Engineering, Oct. 2020, https://doi.org/10.1088/2516-1091/abc34f.
Lowenthal, Justin, and Sharon Gerecht. “If You Build It, They Will Come.” Circulation Research, vol. 127, no. 2, July 2020, pp. 225–28, https://doi.org/10.1161/CIRCRESAHA.120.317111.
Cho, Hongkwan, et al. “IPSC-Derived Endothelial Cell Response to Hypoxia via SDF1a/CXCR4 Axis Facilitates Incorporation to Revascularize Ischemic Retina.” JCI Insight, vol. 5, no. 6, Mar. 2020, https://doi.org/10.1172/jci.insight.131828.
Pitaktong, Isaree, et al. “Early Vascular Cells Improve Microvascularization Within 3D Cardiac Spheroids.” Tissue Engineering Part C: Methods, vol. 26, no. 2, Feb. 2020, pp. 80–90, https://doi.org/10.1089/ten.tec.2019.0228.
Pruitt, Hawley C., et al. “Collagen Fiber Structure Guides 3D Motility of Cytotoxic T Lymphocytes.” Matrix Biomechanics, vol. 85–86, Jan. 2020, pp. 147–59, https://doi.org/10.1016/j.matbio.2019.02.003.
Blatchley, Michael R., and Sharon Gerecht. “Reconstructing the Vascular Developmental Milieu In Vitro.” Trends in Cell Biology, vol. 30, no. 1, Jan. 2020, pp. 15–31, https://doi.org/10.1016/j.tcb.2019.10.004.
Jia Jia, et al. “Evolutionarily Conserved Sequence Motif Analysis Guides Development of Chemically Defined Hydrogels for Therapeutic Vascularization.” Science Advances, vol. 6, no. 28, 2020, p. eaaz5894, https://doi.org/10.1126/sciadv.aaz5894.
Wei, Zhao, et al. “Hydrogel Vehicles for Sequential Delivery of Protein Drugs to Promote Vascular Regeneration.” Sequential Drug/Gene Delivery in Tissue Engineering & Regenerative Medicine, vol. 149–150, Sept. 2019, pp. 95–106, https://doi.org/10.1016/j.addr.2019.08.005.
Xiao, Yang, et al. “Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs.” Advanced Biosystems, vol. 3, no. 8, Aug. 2019, p. 1900089, https://doi.org/10.1002/adbi.201900089.
Elliott, Morgan B., et al. “Regenerative and Durable Small-Diameter Graft as an Arterial Conduit.” Proceedings of the National Academy of Sciences, vol. 116, no. 26, June 2019, p. 12710, https://doi.org/10.1073/pnas.1905966116.
Jamieson, John J., et al. “Role of IPSC-Derived Pericytes on Barrier Function of IPSC-Derived Brain Microvascular Endothelial Cells in 2D and 3D.” Fluids and Barriers of the CNS, vol. 16, no. 1, June 2019, p. 15, https://doi.org/10.1186/s12987-019-0136-7.
Jamieson, John J., and Sharon Gerecht. “Chipping Away at Blood-Brain-Barrier Modeling.” Cell Stem Cell, vol. 24, no. 6, June 2019, pp. 831–32, https://doi.org/10.1016/j.stem.2019.05.014.
Cho, Hongkwan, et al. “Acellular and Cellular Approaches to Improve Diabetic Wound Healing.” Wound Healing and Fibrosis – State of Play, vol. 146, June 2019, pp. 267–88, https://doi.org/10.1016/j.addr.2018.07.019.
Hickey, John W., et al. “Engineering an Artificial T-Cell Stimulating Matrix for Immunotherapy.” Advanced Materials, vol. 31, no. 23, June 2019, p. 1807359, https://doi.org/10.1002/adma.201807359.
Blazeski, Adriana, et al. “Engineered Heart Slice Model of Arrhythmogenic Cardiomyopathy Using Plakophilin-2 Mutant Myocytes.” Tissue Engineering Part A, vol. 25, no. 9–10, May 2019, pp. 725–35, https://doi.org/10.1089/ten.tea.2018.0272.
Lewis, Daniel M., et al. “A Feedback Loop between Hypoxia and Matrix Stress Relaxation Increases Oxygen-Axis Migration and Metastasis in Sarcoma.” Cancer Research, vol. 79, no. 8, Apr. 2019, p. 1981, https://doi.org/10.1158/0008-5472.CAN-18-1984.
Blatchley Michael R., et al. “Hypoxia and Matrix Viscoelasticity Sequentially Regulate Endothelial Progenitor Cluster-Based Vasculogenesis.” Science Advances, vol. 5, no. 3, 2019, p. eaau7518, https://doi.org/10.1126/sciadv.aau7518.
Wei, Zhao, and Sharon Gerecht. “A Self-Healing Hydrogel as an Injectable Instructive Carrier for Cellular Morphogenesis.” Biomaterials, vol. 185, Dec. 2018, pp. 86–96, https://doi.org/10.1016/j.biomaterials.2018.09.003.
Smith, Quinton, et al. “Cytoskeletal Tension Regulates Mesodermal Spatial Organization and Subsequent Vascular Fate.” Proceedings of the National Academy of Sciences, vol. 115, no. 32, Aug. 2018, p. 8167, https://doi.org/10.1073/pnas.1808021115.
Smith, Quinton, et al. “Differential HDAC6 Activity Modulates Ciliogenesis and Subsequent Mechanosensing of Endothelial Cells Derived from Pluripotent Stem Cells.” Cell Reports, vol. 24, no. 4, July 2018, pp. 895-908.e6, https://doi.org/10.1016/j.celrep.2018.06.083.
Jaber, Sausan M., et al. “Sex Differences in the Mitochondrial Bioenergetics of Astrocytes but Not Microglia at a Physiologically Relevant Brain Oxygen Tension.” Mitochondria in the Nervous System: From Health to Disease Part 2, vol. 117, July 2018, pp. 82–90, https://doi.org/10.1016/j.neuint.2017.09.003.
Lewis, Daniel M., et al. “Microfluidic Platform for the Real Time Measurement and Observation of Endothelial Barrier Function under Shear Stress.” Biomicrofluidics, vol. 12, no. 4, May 2018, pp. 042202–042202, https://doi.org/10.1063/1.5026901. PubMed, 29861813.
Smith, Quinton, and Sharon Gerecht. “Extracellular Matrix Regulation of Stem Cell Fate.” Current Stem Cell Reports, vol. 4, no. 1, Mar. 2018, pp. 13–21, https://doi.org/10.1007/s40778-018-0111-2.
Chan, Xin Yi, et al. “Let’s Get Physical: Biomechanical Influences on Human Pluripotent Stem Cell Differentiation towards Vascular Engineering.” Futures of Biomedical Engineering: Cardiovascular Bioengineering and Vascular Biomechanics, vol. 5, Mar. 2018, pp. 42–49, https://doi.org/10.1016/j.cobme.2018.01.001.
Lewis, Daniel M., et al. “Collagen Fiber Architecture Regulates Hypoxic Sarcoma Cell Migration.” ACS Biomaterials Science & Engineering, vol. 4, no. 2, Feb. 2018, pp. 400–09, https://doi.org/10.1021/acsbiomaterials.7b00056.
Blatchley, Michael, et al. “Hypoxia and Matrix Manipulation for Vascular Engineering.” Biophysical Regulation of Vascular Differentiation and Assembly, 2018, pp. 73–119, https://doi.org/10.1007/978-3-319-99319-5_4.
Wadas, Gina. “Bioengineers Borrow from Electronics Industry to Get Stem Cells to Shape Up.” Johns Hopkins University HUB, 2018, https://sites.duke.edu/gerechtlab/publications/.
Jeminson, J., et al. “Pericyte Derived from Pluripotent Stem Cells.” Biology of Pericytes: Development, Homeostasis and Disease; Advances in Experimental Medicine and Biology, Springer, 2018, https://pubmed.ncbi.nlm.nih.gov/30523593/#:~:text=In%20addition%2C%20pericytes%20have%20emerged,growth%20and%20for%20wound%20healing.&text=Human%20pluripotent%20stem%20cells%20(hPSCs,consistently%2C%20and%20with%20high%20yields.
Gerecht, Sharon. Biophysical Regulation of Vascular Differentiation and Assembly. Springer, 2018, https://sites.duke.edu/gerechtlab/publications/.
Chan, Xin Yi, et al. “Human Pluripotent Stem Cells to Engineer Blood Vessels.” Engineering and Application of Pluripotent Stem Cells, edited by Ulrich Martin et al., Springer International Publishing, 2018, pp. 147–68, https://doi.org/10.1007/10_2017_28.
Jamieson, John J., et al. “Engineering the Human Blood-Brain Barrier in Vitro.” Journal of Biological Engineering, vol. 11, no. 1, Dec. 2017, p. 37, https://doi.org/10.1186/s13036-017-0076-1.
Blatchley, Michael R., and Sharon Gerecht. “Integrin Binding: Sticking around Vessels.” Nature Materials, vol. 16, Sept. 2017, pp. 881–83, https://doi.org/10.1038/nmat4977.
Lewis, Daniel M., et al. “O2-Controllable Hydrogels for Studying Cellular Responses to Hypoxic Gradients in Three Dimensions in Vitro and in Vivo.” Nature Protocols, vol. 12, no. 8, Aug. 2017, pp. 1620–38, https://doi.org/10.1038/nprot.2017.059.
Wei, Zhao, et al. “Dual Cross-Linked Biofunctional and Self-Healing Networks to Generate User-Defined Modular Gradient Hydrogel Constructs.” Advanced Healthcare Materials, vol. 6, no. 16, Aug. 2017, p. 1700523, https://doi.org/10.1002/adhm.201700523.
Park, Kyung Min, et al. “Bioinspired Hydrogels to Engineer Cancer Microenvironments.” Annual Review of Biomedical Engineering, vol. 19, no. 1, June 2017, pp. 109–33, https://doi.org/10.1146/annurev-bioeng-071516-044619.
Smith, Quinton, et al. “Compliant Substratum Guides Endothelial Commitment from Human Pluripotent Stem Cells.” Science Advances, vol. 3, no. 5, May 2017, pp. e1602883–e1602883, https://doi.org/10.1126/sciadv.1602883. PubMed, 28580421.
Eoh, Joon H., et al. “Enhanced Elastin Synthesis and Maturation in Human Vascular Smooth Muscle Tissue Derived from Induced-Pluripotent Stem Cells.” Extracellular Matrix Proteins and Mimics, vol. 52, Apr. 2017, pp. 49–59, https://doi.org/10.1016/j.actbio.2017.01.083.
Kusuma, Sravanti, et al. “Micropattern Size-Dependent Endothelial Differentiation from a Human Induced Pluripotent Stem Cell Line.” Journal of Tissue Engineering and Regenerative Medicine, vol. 11, no. 3, Mar. 2017, pp. 855–61, https://doi.org/10.1002/term.1985.
Macklin, Bria L., and Sharon Gerecht. “Bridging the Gap: Induced Pluripotent Stem Cell Derived Endothelial Cells for 3D Vascular Assembly.” Biological Engineering / Materials Engineering, vol. 15, Feb. 2017, pp. 102–09, https://doi.org/10.1016/j.coche.2017.01.003.
Smith, Quinton, et al. “Engineering Niches for Blood Vessel Regeneration.” Biology and Engineering of Stem Cell Niches, edited by Ajaykumar Vishwakarma and Jeffrey M. Karp, Academic Press, 2017, pp. 479–97, https://doi.org/10.1016/B978-0-12-802734-9.00030-5.